Sle another autoimmune disorder influenced by microbes and diet

The level of sCD14 is highly correlated with disease activity parameters, suggesting the involvement of LPS in lupus development.

SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?

One recent study has described diet-mediated increases of specific microbial genera that are known to be lower in SLE Chen et al. According to the Lupus Foundation of America, about two million Americans currently live with the disease.

Lupus: Can Gut Microbes Make a Difference?

In this review, we aim to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis. Systemic lupus erythematosus is a female-biased disorder. Some studies showed promising results, especially for SLE patients with cardiovascular disease, which has emerged as an important cause of death in patients with SLE 99 This suggests that TLR4 hyperresponsiveness to gut flora which contains LPS plays an essential role in lupus development.

Activation of TLR4 also promotes lupus disease activity in transgenic mice, In addition, repeated injections of LPS into lupus-prone mice resulted in increased autoantibody production and development of glomerulonephritis — Our work shows the potential benefits of modulating gut microbiota, especially by increasing the level of Lactobacilli, in the treatment of lupus.

This suggests that TLR4 hyperresponsiveness to gut flora which contains LPS plays an essential role in lupus development. Unfortunately, the study did not identify the causing agent that ameliorated the disease. However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus.

Incidentally, African Americans have used antibiotics much more frequently than people in West African countries 6465and this may have impacted the differences in lupus prevalence and severity between the two populations.

Elucidation of the roles of gut microbes — as well as the roles of diet that can modulate the composition of gut microbes — in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new therapies.

Although the disease affects both males and females, women of childbearing age are diagnosed nine times more often than men. Despite years of study, the etiology of SLE is still unclear. However, little is known on the role of gut microbiota in systemic lupus erythematosus SLE Among these are autoimmune disorders that include inflammatory bowel disease IBD 78type 1 diabetes T1D 9 — 12rheumatoid arthritis 513 — 15and multiple sclerosis 162.

November | Volume 6 | Article Mu et al. Is SLE Infiuenced by Microbes and Diet Frontiers in Immunology | vsfmorocco.com lupus symptoms in lupus mice also restored gut colonization of.

Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and.

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· SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? Qinghui Mu, 1 Husen Zhang, 2 and Xin M. Luo 1, * 1 Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, USACited by:  · Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new vsfmorocco.com by: Researchers at Virginia Tech have recently discussed the contribution of diet and gut microbes to SLE occurrence and pathogenesis in a publication entitled “ SLE: Another Autoimmune Disorder influenced by Microbes and Diet?” published in the journal Frontiers in Immunology.

SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? Qinghui Mu 1, Husen Zhang 2 and Xin M. Luo 1 * 1 Department of Biomedical Sciences Cited by:

Sle another autoimmune disorder influenced by microbes and diet
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